Breakthrough plant‑based biomimetic peptide

Discovered in 1900, L-Carnosine is a natural small molecule dipeptide composed of L-histidine and β-alanine , and is widely present in the human body. For many years, L-Carnosine has been widely used in cosmetics and health food. 

1. Block glycation & oxidation, target multiple pathways, achieve skin longevity

Particularly, L-Carnosine has fantastic anti-glycation effect. It preferentially binds to free sugar, blocking the glycation reaction between collagen and free sugar, thereby reducing AGEs, maintaining skin elasticity and radiance.

2. Next-generation production technology

Our fermentation‑derived biomimetic L-Carnosine is the next-generation choice for natural products and eco-friendly.

3. Proven efficacy

3.1 ABTS radical scavenging test

ABTS is a classic and widely used industry method for evaluating antioxidant capacity. The antioxidant capacity of L-Carnosine is as follows,

Conclusion: At 50 mM L-Carnosine (1.13% dosage), the ABTS radical scavenging rate reaches around 85%, demonstrating very strong antioxidant capacity.

3.2 Reduce telomere damage and shortening rate

Lane M: Molecular weight marker, used to determine telomere length. The higher (on the gel), the longer the telomeres.

PDs (Population Doublings): The number of times cells have divided. The more divisions, the older the cells. Under normal circumstances, telomeres shorten as the number of divisions increases.

Results:

Control: Telomeres shortened markedly with increasing PDs, already greatly reduced by PD43.

Carnosine (20 mM): At PD48, telomeres remained significantly longer than controls, with much slower shortening.

Conclusion: L-Carnosine significantly delays telomere shortening in human skin fibroblasts, extending replicative lifespan and slowing cellular aging.

3.3 Anti-glycation, cell protection

Normal fibroblasts – well-spread shape, orderly cytoskeleton (Red & Green), able to produce collagen and elastin.

Glycated fibroblasts – irregular shape, disordered cytoskeleton, large gaps in green, abnormal red clumps, loss of collagen/elastin production.

After 0.25% L-Carnosine treatment (7 days) – cytoskeleton restored to near normal.

Conclusion: L-Carnosine prevents glycation damage and repairs cells, restoring their ability to produce collagen and elastin, achieving anti-glycation and anti-aging effects.

3.4 In vivo test with 2% UNIBIO_CARNOSINE cream

 Crow’s feet area 

Results: 28-day use of 2% UNIBIO_CARNOSINE cream significantly improved skin radiance and reduced crow's feet area.

Conclusion: 2% UNIBIO_CARNOSINE has excellent anti-aging effects.

INCI：CARNOSINE

CAS：305-84-0

MOLECULAR STRUCTURE：

Why Choose UNIBIO_CARNOSINE?

1. Natural source, produced from corn, with a natural index of 100% according to ISO 16128. 

2. High safety, no risk of hydrazine hydrate.

3. High efficacy, small molecule for easy absorption.

4. Multi-functional, Anti-Glycation, Antioxidant, Anti-Aging, Whitening,etc.

5. Easy to apply, water-soluble.

6. 100% biodegradable and eco-friendly.