Cyclopeptides active ingredients have attracted growing attention in the personal care market, due to their superior stability, better skin penetration and greater target specificity compared with linear peptides.

The main components of our UNI_CYCLOTIDE HB product are cyclotides sourced from Pseudostellaria heterophylla. 

The planting region boasts unique karst landforms and a mild, misty climate. These superior growing conditions facilitate the accumulation of natural cyclotides, with Heterophyllin B as the core cyclotide marker.

Heterophyllin B activates the skin’s endogenous retinoic acid metabolic system to deliver "retinoid-like anti-aging efficacy" with "lower irritation".

It upregulates metabolic enzymes CYP1A1/A2, etc to convert endogenous retinol into active retinoic acid, and elevates RARγ, the predominant retinoic acid receptor in human skin. 

It also increases DHRS3 expression to provide a buffering protective effect, reducing excess retinaldehyde and preventing irritation induced by over‑activated retinoid signaling. Molecular simulation predicts that Heterophyllin B itself can bind to retinoic acid receptor RARγ, generating synergistic retinoic acid‑mimicking anti-aging activity.

UNIBIO_CYCLOTIDE HB has excellent anti-aging effects, as follows, 

1. At 0.1% concentration, retinol and UNIBIO_CYCLOTIDE HB significantly increased type I collagen concentration by 15% and 16%, respectively. 

UNIBIO_CYCLOTIDE HB delivers excellent anti‑aging efficacy, with better performance than retinol.

2. At 0.1% concentration, retinol and UNIBIO_CYCLOTIDE HB significantly increased Lumican concentration by 38% and 43%, respectively. 

UNIBIO_CYCLOTIDE HB delivers superior effects in improving fragile and sagging skin, outperforming retinol.

3. 1% UNIBIO_CYCLOTIDE HB emulsion, 28‑day application. The change rate of total skin thickness increased by +10.87%, dermal density increased by +23.17%, and the overall wrinkle depth change rate was -20.11%. 1% UNIBIO_CYCLOTIDE HB shows excellent anti‑aging efficacy.

INCI: LACTOBACILLUS FERMENT, PSEUDOSTELLARIA HETEROPHYLLA EXTRACT

Heterophyllin B MOLECULAR STRUCTURE：

Why Choose UNIBIO_CYCLOTIDE HB?

1. Highly potent, cyclic structure delivers greater stability, improved skin absorption and better target specificity.

2. Potent anti-aging activity with retinoic acid‑mimicking effects while being milder to skin.

3. Natural fermentation process with endophyte of Pseudostellaria heterophylla.

4. High content of Heterophyllin B ≥100 ppm.

5. Natural source, with a natural index of 100% according to ISO 16128.

6. Readily biodegradable and eco‑friendly.

We also have a directly extracted version, UNI_CYCLOTIDE HB.